When this refrigerator-stable vaccine is reconstituted as directed, each 0.5 mL dose contains the following: a minimum of 1350 plaque forming units (PFU) of Oka/Merck varicella virus, approximately 18 mg of sucrose, 8.9 mg of hydrolyzed gelatin, 3.6 mg of urea, 2.3 mg of sodium chloride, 0.36 mg of monosodium L-glutamate, 0.33 mg of sodium phosphate basic, 57 mcg of potassium phosphate monobasic, 57 mcg of potassium chloride. Varicella virus vaccine live (Oka/Merck) is a lyophilized preparation. Preparation of experimental, refrigerator-stable varicella vaccine samples Thus, recombinant human gelatin, FG-5001, demonstrated a similar ability to stabilize the live attenuated VZV (Oka/Merck) in an experimental refrigerator-stable varicella vaccine when compared to the vaccine preparation formulated with a hydrolyzed porcine gelatin. Even more importantly, vaccine virus potency losses associated with a long-term storage under accelerated conditions at 15☌ for 12 months and real-time conditions at -15☌ and at 2–8☌ for 24 months were similar for both hydrolyzed porcine gelatin- and recombinant human gelatin-stabilized vaccines. VZV (Oka/Merck) potency change after a short-term stability study under accelerated conditions (37☌ for 7 days) was similar for both vaccine preparations. Moreover, the short-term, as well as long-term VZV (Oka/Merck) potency stability under accelerated and real-time storage conditions was evaluated in a comparative study. The stabilizing effect of FG-5001 on VZV (Oka/Merck) during vaccine lyophilization was assessed. VZV (Oka/Merck) was harvested in two formulations prepared with either a hydrolyzed porcine gelatin or FG-5001. ![]() ![]() In this study, FG-5001 was evaluated as a potential replacement for hydrolyzed porcine gelatin in an experimental refrigerator-stable varicella vaccine formulation. FG-5001 is a low molecular weight human sequence-based gelatin fragment (8.5 kDa) that can be used as a substitute for animal-derived material and has been shown to function as an effective alternative stabilizing ingredient in a live attenuated influenza vaccine. To support this goal, recombinant human gelatin, termed FG-5001, was obtained using a yeast expression system and a completely defined fermentation and purification process (FibroGen, Inc., South San Francisco, CA). ![]() The implementation of alternative, well-defined substitutes for biological materials of human or animal origin in vaccine formulations is a desirable trend in pharmaceutical industry. In contrast, use of non-hydrolyzed gelatin in vaccine formulations by Japanese vaccine makers in the past led to higher incidence of gelatin-specific immediate-type hypersensitivity reactions in vaccinated subjects in Japan. Currently, the incidence of anaphylactic reactions to the hydrolyzed porcine gelatin is very low (approximately 1 case per 2 million doses). Low molecular weight gelatin is less likely to stimulate gelatin-specific IgE than high molecular weight gelatin in vaccinated subjects. Hydrolysis converts high molecular weight gelatin (>100,000 Da) to low molecular weight gelatin (between 20 Da). The current manufacturing process of hydrolyzed porcine gelatin yields preparations which consist of a mixture of protein fragments of different sizes. In addition, hydrolyzed gelatin creates and maintains desirable structure/appearance of a lyophilized vaccine cake. It is believed that gelatin provides non-covalent and non-specific protective binding to the virus particles that enhances their stability. The exact mechanism of gelatin-mediated protection to the vaccine virus is unknown. Hydrolyzed porcine gelatin is a major protein/peptide-based component of the final formulation, as well as a component used in the processing of VZV (Oka/Merck) bulk intermediate. The refrigerator-stable varicella vaccine formulation contains stabilizers such as sucrose, hydrolyzed porcine gelatin, phosphate, glutamate, and urea, as well as a live attenuated varicella virus (Oka/Merck) and residual components of MRC-5 cells. The inherent lability of the live varicella virus (Oka/Merck) presents a formulation challenge in terms of stabilizing and preserving vaccine viability during manufacturing, storage and administration. ![]() Varicella virus vaccine live is a lyophilized preparation of live, attenuated VZV (Oka/Merck).
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![]() ![]() And avid players are spending a LOT of time with the app. Like Words With Friends, Pokemon Go is a game that encourages obsessive behavior. That's likely true, but at present, there's a lot of euphoria surrounding Pokemon Go - and people are quite happy to shrug off some responsibilities. "If it eats into their time at work, they know that's going to catch up with them and they're going to face an unhappy boss or coworkers who are counting on them," Taylor says. "It might have a short term impact, but I think most employees who care about their work first will keep it limited to the time they have off," says Lynn Taylor, a national workplace expert and the author of "Tame Your Terrible Office Tyrant: How to Manage Childish Boss Behavior and Thrive in Your Job." (One photo that has already gone viral purports to show a boss getting frustrated with Pokemon-obsessed employees.) In other words, rather than sitting on the couch and collecting the characters, players now explore the real world with smart phones and find them at coffee shops, grocery stores - and even their jobs.Īnd while no one expects the game to cause a breakdown in the work scene, human resource managers could be facing some headaches over the next few weeks, say workplace experts. The app, which debuted on July 6, is already bigger than Tinder and is closing in on the same number of daily active users as Twitter.įor the uninitiated, here's Pokemon Go in a nutshell: It's a virtual scavenger hunt, letting players hunt for 151 different characters on their phones using augmented reality. ![]() And the sudden, phenomenal popularity of Pokemon Go offers a nice respite. There's nothing like a break from the day-to-day routine at your office. ![]() Have we mentioned that a tattoo is forever? It’s totally okay to be picky when looking at tattoo artists' work. Nothing is worse than spending time and money with someone you don't get along with!” Be Picky If, on the other hand, you're planning a substantial piece for your first tattoo, definitely meet with the artist before making an appointment to see if your personalities are compatible. “If you're getting a smaller design, you're probably okay to just set an appointment with the artist you've chosen and get your tattoo. “Find out what you can about their reputation,” advises Tracy. Use Fresh Chalk to ask your friends for recommendations and referrals. Most tattoo shops will have portfolios of their tattoo artists’ work available to browse on their website or Instagram. ![]() Once you’ve figured out the style for your tattoo, do your research and don’t be afraid to shop around. Research Your Local Tattoo Shops & Tattoo Artists Browse the portfolios of lots of different artists before you take the plunge-you may find inspiration for something boldly original. Many tattoo artists have their own unique art style that can result in a truly one of a kind piece. “Once you know what style you want to go with, look for someone that does this style, and does it well!” says Anchor Tattoo’s Tracy Zumwalt. What is the art style of the tattoo you want? Most designs will fall under a specific category-is it Traditional Japanese, Tribal, Traditional American, Realistic? Not every tattoo artist has the same style, or excels in all styles, so identifying that style that speaks to you is important. These tips from Fresh Chalk and Tracy Zumwalt at Anchor Tattoo can help ensure you’ll walk away with an awesome piece of body art that you’ll want to show-off. Thinking of getting your first tattoo but don’t know where to start? Perhaps you have a design in mind, and now you need to find that just-right tattoo artist to bring it to life. ![]() ![]() More info on when/why we remove posts in our moderation standards More Information ![]() Follow us on Duplicate PostsĪny post that is identical in principle to a post made in the last 24 hours will be removed to reduce topic fatigue. FTF is an attempt to reduce topic fatigue. On Fridays, posts can't be highly similar to any other in the past month, and won't show up in the new queue until they've been checked and approved by a moderator. Please report cases of delta abuse/misuse, accidental deltas, and failed delta attempts.Ĭode on GitHub: DeltaBot / CMVModBot Monthly Deltaboard Rank How to not earn a delta: Anti-delta Approach. u/DeltaBot will maintain delta counts in user flair, wiki pages for each user's delta history, record deltas in /r/DeltaLog, and update deltaboards where necessary. Whether you're the OP or not, please reply to the user(s) that change your view to any degree with a delta in your comment (instructions below), and also include an explanation of the change. Jokes, contradictions without explanation, links without context, and "written upvotes" will be removed. ▾Ĭomments should be on-topic, serious, and contain enough content to move the discussion forward. Ĭomments must contribute meaningfully to the conversation. Delta abuse includes sarcastic deltas, joke deltas, super-upvote deltas, etc. You must include an explanation of the change along with the delta so we know it's genuine. Īward a delta if you've acknowledged a change in your view. If you think they are still exhibiting poor behaviour, please message us. If you are unsure whether someone is genuine, ask clarifying questions (see: socratic method). Refrain from accusing OP or anyone else of being unwilling to change their view, or of arguing in bad faith. Your comment will be removed even if the rest of it is solid. ▾Īrguments in favor of the view OP is willing to change must be restricted to replies to other comments. ĭirect responses to a CMV post must challenge at least one aspect of OP’s stated view (however minor), or ask a clarifying question. If you haven't replied during this time, your post will be removed. Only post if you are willing to have a conversation with those who reply to you, and are available to start doing so within 3 hours of posting. No view is banned from CMV based on popularity or perceived offensiveness, but the above types of post are disallowed for practical reasons. Posts cannot express a neutral stance, a stance on transgender, suggest harm against a specific person, be self-promotional, or discuss this subreddit (visit r/ideasforcmv instead). Posts with misleading/overly-simplistic titles may be removed. Submission titles must adequately sum up your view and include "CMV:" at the beginning. Posts by throwaway accounts must be approved through modmail. You must personally hold the view and demonstrate that you are open to it changing.▾Ī post cannot be made on behalf of others, for playing devil's advocate, as any entity other than yourself, or to "soapbox". Note: if your view is about a "double standard", please see the guidelines here. More Detail Message the Moderators Submission RulesĮxplain the reasoning behind your view, not just what that view is (500+ characters required). Submit a CMV post Deltas from Popular Topics Search CMV What is /r/changemyview?Ī place to post an opinion you accept may be flawed, in an effort to understand other perspectives on the issue.Įnter with a mindset for conversation, not debate. To prevent users from encountering this issue, Copilot in Windows (in preview) might not be available on devices that have been used or are currently being used in a multimonitor configuration. Windows devices using more than one (1) monitor might experience issues with desktop icons moving unexpectedly between monitors or other icon alignment issues when attempting to use Copilot in Windows (in preview). We are working on a resolution and will provide an update in an upcoming release. ![]() To mitigate this issue in Microsoft Intune, you can set the “Enforce drive encryption type on operating system drives” or "Enforce drive encryption on fixed drives" policies to not configured. Important This issue is a reporting issue only and does not affect drive encryption or the reporting of other issues on the device, including other BitLocker issues. Microsoft Intune is affected by this issue but third-party MDMs might also pe affected. Affected environments are those with the “Enforce drive encryption type on operating system drives” or "Enforce drive encryption on fixed drives" policies set to enabled and selecting either "full encryption" or "used space only". Using the FixedDrivesEncryptionType or SystemDrivesEncryptionType policy settings in the BitLocker configuration service provider (CSP) node in mobile device management (MDM) apps might incorrectly show a 65000 error in the "Require Device Encryption" setting for some devices in your environment. ![]() Up to now, comparisons have been conducted using juxtaposed pictures, whether original prints or digital reproductions. Many studies have focused on the semantic and formal comparison of the two main versions of the series. These are the 14 plates of the Invenzioni capricciose di Carceri all’acquaforte. This version, which is more widespread and better known, derives from the reworking of matrices that the Venetian engraver produced in 1749–50. 64.Piranesi printed the 16 etchings of the Carceri d’invenzione in 1761. Explore the FOLIO EDITION (12x19 Inches): Available Upon Request. Product Disclaimer: Kindly be informed that, owing to the inherent nature of leather as a natural material, minor discolorations or textural variations may be perceptible. We eagerly await your feedback, hoping that you'll find it appealing and will generously share your thoughts and recommendations. Our intention is to offer this valuable resource once again. Recognizing their significance for readers seeking insight into our historical treasure, we've diligently restored and reissued them. ![]() We sincerely hope for your understanding of the challenges we faced with these books. However, in certain instances, occasional blurriness, missing segments, or faint black spots might persist. Due to the vintage nature of these books, every page has been manually restored for legibility. A team of professionals has expertly processed each page, delicately preserving its content without alteration. Its durability is ensured through a meticulous sewing binding technique, enhancing its longevity. The contents of this book are presented in classic black and white. If it is multi volume set, then it is only single volume, if you wish to order a specific or all the volumes you may contact us. This masterpiece has been meticulously Reprinted in 2023, utilizing the invaluable guidance of the original edition published many years ago in 1913. The allure continues with Golden Leaf Printing that adds a touch of elegance, while Hand Embossing on the rounded spine lends an artistic flair. ![]() Presenting an Exquisite Leather-Bound Edition, expertly crafted by the prestigious organization "Rare Biblio" with Original Natural Leather that gracefully adorns the spine and corners. Select Your Preferred Color at No Additional Cost! Explore More Options by Clicking on 'More Images' and Notify Us of Your Choice via Email. GET INTO THE HOLIDAY SPIRIT WITH OUR SPECIAL CHRISTMAS AND NEW YEAR OFFERS! BUT DON'T WAIT THIS DEAL WON'T LAST LONG! GRAB YOUR GIFTS NOW BEFORE THIS FESTIVE OFFER DISAPPEARS LIKE SNOWFLAKES IN THE HOLIDAY JOY. Sewing binding for longer life, where the book block is actually sewn (smythe sewn/section sewn) with thread before binding which results in a more durable type of binding. IF YOU WISH TO ORDER PARTICULAR VOLUME OR ALL THE VOLUMES YOU CAN CONTACT US. If the original book was published in multiple volumes then this reprint is of only one volume, not the whole set. Fold-outs, if any, are not part of the book. As this print on demand book is reprinted from a very old book, there could be some missing or flawed pages, but we always try to make the book as complete as possible. Each page is checked manually before printing. Illustrations, Index, if any, are included in black and white. This is NOT a retyped or an ocr'd reprint. NO changes have been made to the original text. Bound in genuine leather with Satin ribbon page markers and Spine with raised gilt bands. Leather Binding on Spine and Corners with Golden leaf printing on spine. ![]() Flash has done an awesome job of pulling the braces up on browsers for the last decade, and we've needed it, but Flash is so much more than just video or font rendering. The native video element will (eventually) allow us to drop using Flash for video. sIFR is used to bring "custom" fonts to the browser, but now we have really good support for native custom fonts via the CSS fonts module, and products like TypeKit and FontDeck are making it easy for web authors to include those custom fonts without the need of Flash. I think HTML5 and the Open Web will replace Flash where Flash has been used as a stopgap. I personally don't think HTML will replace Flash. Would you like to see Flash replaced by HTML? Adobe released Buzzword which relies on Flash, but on the other side we have Google Docs which relies entirely on the Open Web. This ranges from the simple image galleries to full fledged word processors. There's lots of examples of apps and effects that have been achieve using Flash in the first decade of this century, but today we can build these using Open Web technologies. WebGL is very much at an early stage in it's development, only really (currently) appearing in the nightly builds of Webkit and Firefox, equally I've seen videos from Mozilla putting WebGL on to a Nokia device with no optimisation and it being able to render pretty well. HTML, SVG, CSS and JavaScript are very far along to replacing a lot of what I see Flash doing today - but it should be noted my browsing style is general usage, rather than gaming or interactive videos - which Flash is good at. How far is HTML (and SVG and CSS and WebGL and JavaScript) to reproducing what Flash can do today? I've published 38 videos for new developers, designers, UX, UI, product owners and anyone who needs to conquer the command line today. I can’t stop feeling my lashes! It really feels like the Boy Brow for your lashes - it defines your lashes and makes them soft. Lash Slick, however, not only makes my lashes feel soft and fluttery, but it also makes me feel like I’m wearing nothing - it’s basically weightless. when I apply mascara to my top and bottom lashes, sometimes they have the tendency to stick together whenever I close my eyes. It’s kinda weird to say this, but there are times when I feel like there’s something in my eyes when I usually wear mascara (i.e. Other than that, my lashes are definitely lengthened and separated. Notice that it instantly weighs my lashes down. This is how my lashes look after I curled them:Īnd this is how my lashes look after Lash Slick:Īnd I curled my lashes again after applying Lash Slick: I’m looking for a long lasting mascara that will hold curls, and will not smudge. After using an irritating mascara (Covergirl Supersizer waterproof) for a prolonged period of time, my lashes became fine and weak. So I have straight, short, and fine lashes. I am Asian, and most Asians have straight, short lashes. Some background about my lashes and what I look for in a mascara: I’ve been diligent in keeping up with the beauty industry and when Glossier launched its first mascara, I had to try it for myself! After all, I’m super picky about mascaras. Wow, I’ve been very busy for the past few months, and haven’t been able to write on this blog for awhile. ![]() If I don’t do this, my brows will fall back in place.Īfter I powder the areas where I applied the concealer with Innisfree’s powder, I lightly sweep my Butter Bronzer all over my lids, focusing more product on the outer half to deepen it. This is important: I gently hold my brows in place with my finger and lightly wipe off excess product. I create hairlike strokes with my brow pencil from Etude House, then finish off with my Boy Brow in Black. Then I go ahead with my Glossier Stretch Concealer in Medium, and focus them under my eyes, around my nose, chin and temples. This is a perfect mix because the sunscreen has a super strong white cast and the tint (which is slightly darker than my skin) neutralizes it, while also blurring my skin slightly. Next I mix my Innisfree sunscreen and Glossier Skin Tint in Medium(btw, I heard this was reformulated recently. I like to keep my skincare routine fairly minimal. I go ahead with my usual skincare products: Etude House toner, The Ordinary Matryxl (will use this forever), and The Ordinary squalane (will use this forever too). It does a good job with cleansing and agrees well with my super sensitive skin. However, I got used to the feeling and find the light scent to be very pleasant as well. ![]() When I first used it, I could not get used to how it does not foam up. The colors here really suit my skin tone and hair color, and goes well with any virtually any outfit.įirst, I cleanse with Milky Jelly Cleanser. ![]() It’s not too different from my regular routine (it’s actually almost identical), but just wanted to show my (literal) everyday look. After the launch of Lash Slick, a (almost) full face of Glossier is finally possible. ![]() The Lounge São Paulo is located in Terminal 2 - Domestic, in the restricted area, in the Mezzanine between the rooms of GOL and Bradesco.įollowing the architectural line of the other Global Lounge Network lounges around the world, The Lounge São Paulo has different rest areas, as well as a Business Center with private cabins, Kids area, Zen Space, men and women bathrooms, male and female showers and PNE bathroom. THE LOUNGE SÃO PAULO Terminal 2 - D omestic area (M ezzanine) * Entrance for adults is BRL 175.00 for 3 hours of lounge access and BRL 115,00 for 1 hour of lounge access. ![]() Wi-fi and other amenities of a VIP lounge. With food and beverage service, sparkling wine, meeting room and digital magazines. It also functions as a meeting point for our recently launched Meet & Assist Allways service in GRU. The environment is inclusive and suitable for the different moments of the passenger in their arrivals, departures and in transit of national and international trips. ![]() Learn more about the Plaza Premium Lounge here. Reservation and information center: +55 11 93420-4493 - lounge for all travelers, regardless of airline, flight class or credit card status. * AMEX Cards issued abroad, Capital One (Venture) Visa Airport Companion App and DragonPass customers can enjoy complimentary access. * Entrance for adults is BRL 215.00 for 3 hours of lounge access and BRL 140,00 for 1 hour of lounge access. We also have showers, high-speed Wi-Fi, workstations, Kids space, TV channels, international newspapers and digital magazines and, for those who need a little more privacy, we offer a comfortable and exclusive conference room, ideal for meetings. Lounge offerings include a wide selection of food and drinks, ranging from hot dishes and fresh food to a wide range of soft drinks and alcoholic beverages. With a breathtaking view, this lounge is an architectural masterpiece of modern design and sustainability, providing the perfect balance between a space for work and relaxation, entertainment and dining experience. Reservation and information center: + 55 11 93420-4493 - Premium Lounge (Domestic Departures, Terminal 2) | plaza premium loungeĪ lounge for all travelers, regardless of airline, flight class or credit card status. Offers plugs for chargers throughout the room, WiFi and shower (the shower service is an extra service that the customer can add to their purchase). The cost is BRL 180.00 reais and includes a varied local gastronomic offer (there are also gluten-free options available), a drinks menu including alcoholic drinks, soft drinks and hot drinks. ![]() The Lounge also has direct partners: C6 Bank, Inter, Sisprime and Credicoamo.Ĭ ustomers can also purchase access by paying directly at reception. * You must download the application of the program you want to use and check all access conditions. T he W Premium Group has VIP lounge access programs such as: Lounge key, Priority Pass and Visa Airport Companion. The space is welcoming and allows customers to enjoy a wonderful experience, from the moment they arrive at the airport, to preparing for boarding. Įlegance, comfort and exclusivity are the main qualities that our lounges convey. Email: Media: W Lounge São Paulo (GRU) is the exclusive lounge in Terminal T1. Reddit can be used for so many purposes and various tech-niche sites like The Usables are contributing great to help netizens get to know more about tech and gadgets. Moderators of NSFW subreddits prescribe strict guidelines for admissibility. User-driven platforms like Reddit have more potential for creators, connoisseurs, and community seekers. Redditlist sifts through all subreddits using daily rankings and statistics for the unchartered experiences. It welcomes open-minded redditors who want to disseminate user-submitted, amateurish and curated content different from mainstream NSFW sites. NSFW Reddit is the go-to destination for users on the prowl for simple NSFW, GIFs, Reddit Gone Wild and other similar genres. If you wiggle through the Pillowfort’s fortified wall, you’ll have a chance to feast your eyes on plethora NSFW. In the wake of the Tumblr mass exodus, Pillowfort’s invites have become scarce due to the influx of refugees. Moreover, Pillowfort has a lenient policy regarding NFSW content and offers users optimum control. Users like or re-blog posts, reply to posts, follow categories or profiles, and communicate via mail with other members. The key pops up as an invite that allows a glimpse to a feed that looks like Tumblr’s dashboard. It works as a private system with a key as an extra layer of security. Pillowfort’s low profile defies its peak blogging machinery made from superior website capabilities, design, and user experience. Numerous Mastodon instances like Lewd, Art Alley and Humblr have a wealth of NSFW media. This plays a pivotal role in the NSFW world. As opposed to tweets, users anonymously publish “toots” with restricted accessibility for followers.įor starters, this complexity should not scare you off because it seeks to give more control or privacy to users for their content. Users can interconnect across these servers and create communities. It falls under Fediverse, a decentralized ecosystem of servers hosting a network of mini-servers dubbed Mastodon instances. Mastodon is in the frontline of social media platforms seeking to replace outgoing giants like Tumblr. You can save your naughty content from oblivion by exporting it to this platform.īest of all, Mamby will pay you in BTC for each view your content received. Mamby offers an NSFW version of Instagram and that’s why many users prefer it over other social sites. Users scroll through a treasure of content tailored to their preferences on an intuitive interface. Images, videos, GIFs and creative writing give you leeway to craft an individual profile. Mamby provides a dynamic way to quench your thirst for bespoke content. Sites from our list are secure spaces for artists or digital communities that had been left in the cold. We combed the list of Tumblr-like platforms where you can still find and share your NSFW content. Since then many Tumblr users are looking for sites that still allow such kind of content. Many cheered when Tumblr announced this move, but for many lovers of NSFW content, this was a heavy blow. ![]() ![]() "We do see young girls being victims of sextortion as well, but they are targeted in a different way.In fall last year, Tumblr implemented stringent rules banning obscene or NSFW content and comments. "Statistically speaking, 90 per cent of the victims that we see are boys or young boys, and 56 per cent of those young boys are aged 16 to 17 years, and 35 per cent are aged 13 to 15 years," she said Ms Schneider said more males fall victim to sextortion. ![]() "In fact, we estimate only one in 10 report." "It's certainly an offence that we feel is very under-reported here in Australia," she said.
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